The short clinical study is devoted to the corrective action of the neurotropic drug LEVOPA (L-DOPA) in patients with coronary artery disease (CAD) complicated by atherogenic dyslipidemia (DLP), moderate angina pectoris (AP), arterial hypertension (AH) and other risk factors for the development of atherosclerosis (AS). Purposefully in neurology, drug of L-DOPA - LEVOPA is used in significant doses (3-10 g/day) to treat Parkinsons disease, including atherosclerotic genesis. In this study, the neurotropic drug LEVOPA was used as an active metabolic agent in the complex therapy of CAD in a small dose of 0.5 g 3 times a day, with chronic oral administration for 4 weeks. As a result, an improvement in the lipid profile of blood and the hypolipidemic property of the drug LEVOPA were found. An improvement in hemodynamics and general well-being was noted in treated patients with aggravating risk factors for the development of AS. We had notice the decrease of lipid peroxidation (LPO) too.

Endophytic fungi always attract attention due to their generous production of bioactive and chemically novel compounds that have medical, agriculture, industrial applications. This review focused on Chaetomium as a model of endophytic fungi rich in therapeutic agents that have known medicinal and industrial application. Moreover, understanding the importance of this potent fungus encourage further studies to identify novel metabolites, and at the same time employing already known metabolites to evaluate their activity in order to be used in additional applications.

Cochliobolus is a Dematiaceous fungi that belong to family: Pleosporaceae. It is known as worldwide pathogen of mostly grasses that caused devastating disease epidemics of important economic food crops as wheat, rice, and maize. Many Cochliobolus species have their asexual states, and consequently synonyms, in either Bipolaris or Curvularia. In this review, highlights were presented on Cochliobolus species as models of fungi rich in therapeutic agents that can be employed in different applications. Moreover, describing the importance and potentials of this fungus in order to encourage for further studies to search, isolate, and purify already known metabolites. Also, screen for, and discover novel metabolites produced by those potent fungi in order to be involved in additional applications.

Fungi generally and endophytic ones specifically represent future factories and potent biotechnological tools for production of bioactive natural substances, which could extend healthy life of humanity. Pestalotiopsis is a fungal genus that belongs to family; Sporocadaceae, has been known as a promising secondary metabolites producer. However the same fungus showed harmful pathogenicity against different plants causing crops economical losses. This review is to demonstrate secondary metabolites from the endophytic fungi Pestalotiopsis and some of its reported biological activities. Moreover, describing the unique chemical diversity of this fungal genus involved in medical, pharmaceutical, agricultural applications. Also highlight the harmful side of this important fungus.

Green science is else called sustainable sciences. The structure is utilized of chemical compounds and techniques that diminish age of perilous i.e. hazardous compound substances. Green science applies corner to corner the life-cycle of a chemical compound, including its assembling, use, plan, and at last removal. Green science is extremely useful in avoidance of contamination at the atomic level, it gives creative scientific arrangements, and it lessens the negative effects of compound on human health and the environment. Green sciences 12 standards (Prevent squander, Maximize particle economy, Plan less risky concoction amalgamation, Design more secure synthetic concoctions and items, Use more secure solvents whats more, response conditions and Increase vitality productivity and so on.). Green science assume significant job in pharmaceutical in creating innovatory medicate conveyance strategies which are not so much poisonous but rather more valuable, viable with least symptoms and could help a large number of patients.